Prevalence and correlates of obstructive sleep apnoea among patients with and without HIV infection.

Autor:	Kunisaki, KM, Akgün, KM, Fiellin, DA, Gibert, CL, Kim, JW, Rimland, D, Rodriguez‐Barradas, MC, Yaggi, HK, Crothers, K
Předmět:	ANALYSIS of covariance CHI-squared test CONFIDENCE intervals HIV-positive persons LONGITUDINAL method VETERANS MEDICAL cooperation SCIENTIFIC observation QUESTIONNAIRES RESEARCH RESEARCH funding SLEEP apnea syndromes STATISTICS T-test (Statistics) DATA analysis MULTIPLE regression analysis DISEASE prevalence DATA analysis software DESCRIPTIVE statistics ODDS ratio DISEASE risk factors
Zdroj:	HIV Medicine; Feb2015, Vol. 16 Issue 2, p105-113, 9p
Abstrakt:	Objectives In HIV-uninfected populations, obstructive sleep apnoea ( OSA) is commonly associated with cardiovascular disease, metabolic syndrome, and cognitive impairment. These comorbidities are common in HIV-infected patients, but there are scarce data regarding OSA in HIV-infected patients. Therefore, we examined the prevalence and correlates of OSA in a cohort of HIV-infected and uninfected patients. Methods An observational cohort study was carried out. Electronic medical record and self-report data were examined in patients enrolled in the Veterans Aging Cohort Study ( VACS) between 2002 and 2008 and followed until 2010. The primary outcome was OSA diagnosis, determined using International Classification of Diseases, 9th edition ( ICD-9) codes, in HIV-infected compared with uninfected individuals. We used regression analyses to determine the association between OSA diagnosis, symptoms and comorbidities in adjusted models. Results Of 3683 HIV-infected and 3641 uninfected patients, 143 (3.9%) and 453 (12.4%) had a diagnosis of OSA (p < 0.0001), respectively. HIV-infected patients were more likely to report symptoms associated with OSA such as tiredness and fatigue. Compared with uninfected patients with OSA, HIV-infected patients with OSA were younger, had lower body mass indexes ( BMIs), and were less likely to have hypertension. In models adjusting for these traditional OSA risk factors, HIV infection was associated with markedly reduced odds of OSA diagnosis (odds ratio 0.48; 95% confidence interval 0.39-0.60). Conclusions HIV-infected patients are less likely to receive a diagnosis of OSA. Future studies are needed to determine whether the lower prevalence of OSA diagnoses in HIV-infected patients is attributable to decreased screening and detection or to a truly decreased likelihood of OSA in the setting of HIV infection. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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