Computational Analysis Reveals the Association of Threonine 118 Methionine Mutation in PMP22 Resulting in CMT-1A.

Autor:	Kumar, Chundi Vinay, Swetha, Rayapadi G., Anbarasu, Anand, Ramaiah, Sudha
Předmět:	CHARCOT-Marie-Tooth disease MYELIN proteins THREONINE GENETIC mutation METHIONINE SINGLE nucleotide polymorphisms PERIPHERAL nervous system
Zdroj:	Advances in Bioinformatics; 2014, p1-10, 10p
Abstrakt:	The T118M mutation in PMP22 gene is associated with Charcot Marie Tooth, type 1A (CMT1A). CMT1A is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Mutations in CMT related disorder are seen to increase the stability of the protein resulting in the diseased state. We performed SNP analysis for all the nsSNPs of PMP22 protein and carried out molecular dynamics simulation for T118M mutation to compare the stability difference between the wild type protein structure and themutant protein structure. Themutation T118M resulted in the overall increase in the stability of themutant protein. Thesuperimposed structure shows marked structural variation between thewild type and themutant protein structures. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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