Oxidative tandem nitrosation/cyclization of N-aryl enamines with nitromethane toward 3-(trifluoromethyl)quinoxalines.

Autor: Zhi-Jun Yang, Chuan-Zhuo Liu, Bo-Lun Hu, Chen-Liang Deng, Xing-Guo Zhang
Předmět:
Zdroj: Chemical Communications; 2014, Vol. 50 Issue 93, p14554-14557, 4p
Abstrakt: A novel one-pot strategy for the synthesis of 3-trifluoro-methylquinoxalines from N-aryl enamines and nitromethane was developed. The tandem reaction is achieved through nitrosation of alkenes, tautomerization and cyclization, which can be applicable to a wide range of enamines with excellent functional group tolerance and afford quinoxalines in moderate to good yields. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index