Cleavage of unactivated amide bonds by ammonium salt-accelerated hydrazinolysis.

Autor: Yuhei Shimizu, Megumi Noshita, Yuri Mukai, Hiroyuki Morimoto, Takashi Ohshima
Předmět:
Zdroj: Chemical Communications; 2014, Vol. 50 Issue 84, p12623-12625, 3p
Abstrakt: Hydrazinolysis of unactivated amide bonds is significantly accelerated by the addition of ammonium salts. The reactions proceed at 50-70 °C to give amines with broad substrate scope that outperforms existing amide bond cleavage reactions. Application to peptide and amino sugar derivatives is also demonstrated. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index