Common variants in CYP2R1 and GC genes are both determinants of serum 25-hydroxyvitamin D concentrations after UVB irradiation and after consumption of vitamin D3--fortified bread and milk during winter in Denmark.
Autor: | Nissen, Janna, Vogel, Ulla, Ravn-Haren, Gitte, Andersen, Elisabeth W., Madsen, Katja H., Nexø, Bjørn A., Andersen, Rikke, Mejborn, Heddie, Bjerrum, Poul J., Rasmussen, Lone B., Wulf, Hans Christian |
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Předmět: |
DNA analysis
VITAMIN D metabolism ENRICHED foods ALLELES BREAD CHI-squared test CLINICAL trials HUMAN skin color STATISTICAL correlation DIET GENETIC polymorphisms NONIONIZING radiation MILK NUTRITION PROBABILITY theory PUBLIC health RESEARCH evaluation RESEARCH funding STATISTICAL sampling SELF-evaluation STATISTICS ULTRAVIOLET radiation VITAMIN D WHITE people GENOMICS STATISTICAL power analysis DATA analysis CHOLECALCIFEROL BODY mass index RANDOMIZED controlled trials PRE-tests & post-tests BLIND experiment DATA analysis software MICROARRAY technology DESCRIPTIVE statistics GENOTYPES |
Zdroj: | American Journal of Clinical Nutrition; Jan2015, Vol. 101 Issue 1, p218-227, 10p, 2 Charts, 1 Graph |
Abstrakt: | Background: Little is known about how the genetic variation in vitamin D modulating genes influences ultraviolet (UV)B--induced 25-hydroxyvitamin D [25(OH)D] concentrations. In the Food with vitamin D (VitmaD) study, we showed that common genetic variants rs10741657 and rs10766197 in 25-hydroxylase (CYP2R1) and rs842999 and rs4588 in vitamin D binding protein (GC) predict 25(OH)D concentrations at late summer and after 6-mo consumption of cholecalciferol (vitamin D |
Databáze: | Complementary Index |
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