| Autor: |
Baruah CC; ICMR Center for Advanced Pharmacological Research on Traditional Remedies, Division of Pharmacology, Central Drug Research Institute, Lucknow, India., Gupta PP, Nath A, Patnaik LG, Dhawan BN |
| Jazyk: |
angličtina |
| Zdroj: |
Pharmacological research [Pharmacol Res] 1998 Dec; Vol. 38 (6), pp. 487-92. |
| DOI: |
10.1006/phrs.1998.0397 |
| Abstrakt: |
Picroliv, a standardised iridoid glycoside fraction from the root and rhizome of Picrorhiza kurroa at a dose of 25 mg kg-1 p.o. inhibited passive cutaneous anaphylaxis in mice (82%) and rats (50-85%) and protected mast cells from degranulation (60-80%) in a concentration-dependent manner. Its effect was also studied in sensitised guinea pig ileum preparation in vitro (Schultz-Dale study) and in normal guinea pigs in vivo (Konzett-Rossler, in preparation). There was inhibition of the Schultz-Dale response in sensitised guinea pig ileum, but the bronchospasm induced by histamine could not be antagonised or prevented by Picroliv, indicating the absence of a direct post-synaptic histamine receptor blocking activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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