| Autor: |
Siddiqui WA, Taylor DW, Kan SC, Kramer K, Richmond-Crum SM, Kotani S, Shiba T, Kusumoto S |
| Jazyk: |
angličtina |
| Zdroj: |
Science (New York, N.Y.) [Science] 1978 Sep 29; Vol. 201 (4362), pp. 1237-9. |
| DOI: |
10.1126/science.99814 |
| Abstrakt: |
Owl monkeys (Aotus trivirgatus griseimembra) were effectively immunized against a human malaria parasite, Plasmodium falciparum. Two injections of antigen, primarily mature segmenters with fully developed merozoites, mixed with adjuvant (6-O-stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine and liposomes) were administered intramuscularly at a 4-week interval. Approximately 2 weeks after the second vaccination, the monkeys were challenged with the homologous strain of P. falciparum. All immunized monkeys survived the challenge. The substitution of Freund's complete adjuvant is an encouraging step toward the development of an effective and safe vaccine for human malaria. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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