The natural history of human immunodeficiency virus 1 infection in Haitian infants.
| Autor: | Jean SS; Cornell University Infectious Diseases Research Unit, Institut National de Laboratoire et de Recherches and Haitian Study Group on Kaposi's Sarcoma and Opportunistic Infections, Port-au-Prince., Pape JW, Verdier RI, Reed GW, Hutto C, Johnson WD Jr, Wright PF |
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| Jazyk: | angličtina |
| Zdroj: | The Pediatric infectious disease journal [Pediatr Infect Dis J] 1999 Jan; Vol. 18 (1), pp. 58-63. |
| DOI: | 10.1097/00006454-199901000-00014 |
| Abstrakt: | Objectives: The current study followed HIV-infected women through pregnancy and their infants through the first 2 years of life to determine the rate of vertical transmission of HIV infection from Haitian women, factors in maternal health and obstetrical history that might influence such transmission and the natural history of HIV infection in their affected offspring. Study Design: The medical histories of 81 infants born of HIV-infected women and of a control group of 88 infants born to uninfected women were documented with close clinical and serologic follow-up. In addition to standard tests for persistence of HIV antibodies, the use of acid-dissociated p24 assays enabled us to assign some additional infants to the HIV-infected cohort. Results: Transmission could be documented in 27% of infants born to HIV-infected women. Excess early deaths occurred in infants of HIV-infected women in Port-au-Prince with 60% of infected infants dead by 6 months of age. This is a more accelerated mortality than that in a group of 42 HIV-infected infants born of Haitian mothers living in Miami where 10% were dead at 6 months. Clinically, in 6 of 19 deaths in HIV-infected children in Haiti, failure to thrive and gastroenteritis lead to a systemic infection manifested as meningitis, sepsis or pneumonia as the immediate cause of death. Conclusions: Early mortality attributable to perinatally acquired AIDS was identified in Haiti. The comparison of data from Miami and Port-au-Prince suggests that environmental exposures in developing countries may be more operative in this early mortality than viral strain or maternal host factors, both of which might be expected to be similar between the two groups of Haitian ethnicity. |
| Databáze: | MEDLINE |
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