Facile synthesis of high affinity styrylpyridine systems as inherently fluorescent ligands for the estrogen receptor.

Autor: Meyers MJ; Department of Chemistry, University of Illinois, Urbana 61801, USA., Carlson KE, Katzenellenbogen JA
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1998 Dec 15; Vol. 8 (24), pp. 3589-94.
DOI: 10.1016/s0960-894x(98)00652-0
Abstrakt: A series of styrylpyridine derivatives containing two phenols was prepared via an efficient two-step synthesis. These compounds were designed to maximize the estrogen receptor binding affinity of a known series of inherently fluorescent styrylpyridines. While significant improvements were achieved in receptor affinity, the fluorescence intensity of this series of compounds is poor.
Databáze: MEDLINE