| Autor: |
Antonelli T; Department of Experimental and Clinical Medicine, University of Ferrara, Italy., Ferraro L, Hillion J, Tomasini MC, Rambert FA, Fuxe K |
| Jazyk: |
angličtina |
| Zdroj: |
Neuroreport [Neuroreport] 1998 Dec 21; Vol. 9 (18), pp. 4209-13. |
| DOI: |
10.1097/00001756-199812210-00038 |
| Abstrakt: |
The ability of modafinil (Modiodal) to protect cortical neurons from glutamate-induced degeneration was evaluated by measuring electrically evoked [3H]GABA release and [3H]GABA uptake in primary cerebral cortical cultures. In normal cells, electrical stimulation (10 Hz, 2 min) increased [3H]GABA release (FR-NER St1 = 0.77+/-0.14; St2/St1 ratio = 0.94+/-0.02). The exposure of sister cells to glutamate, reduced electrically evoked [3H]GABA release (FR-NER St1 = 0.40+/-0.05; St2/St1 ratio = 0.60+/-0.08). Modafinil (0.3-1 microM) prevented the glutamate-induced reduction of the St2/St1 ratio (0.85+/-0.11; 0.88+/-0.05, respectively). A similar protective effect was observed for [3H]GABA uptake. These findings suggest that modafinil may be neuroprotective in that it attenuates glutamate-induced excitotoxicity in cortical neurons. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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