Mutations in 23S rRNA in Helicobacter pylori conferring resistance to erythromycin do not always confer resistance to clarithromycin.

Autor: García-Arata MI; Department of Microbiology, Hospital Ramón, Madrid, Spain., Baquero F, de Rafael L, Martín de Argila C, Gisbert JP, Bermejo F, Boixeda D, Cantón R
Jazyk: angličtina
Zdroj: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1999 Feb; Vol. 43 (2), pp. 374-6.
DOI: 10.1128/AAC.43.2.374
Abstrakt: Mutations conferring resistance to erythromycin or clarithromycin in Helicobacter pylori were studied. Mutation A2142G was consistently associated with clarithromycin MIC of > 256 micrograms/ml, whereas mutants carrying A2143G had MICs ranging from < or = 0.016 to > 256 micrograms/ml, suggesting that additional factors account for the observed multiple levels of resistance to clarithromycin.
Databáze: MEDLINE