[Immune modulating effect of intravenous gamma globulin in a patient with overlapping syndrome].

Autor: Jurlow E; Departamento de Medicina Experimental, Facultad de Medicina, Universidad de Chile, Santiago de Chile., Poblete P, Marinovic MA
Jazyk: Spanish; Castilian
Zdroj: Revista medica de Chile [Rev Med Chil] 1998 Sep; Vol. 126 (9), pp. 1108-11.
Abstrakt: We report a 46 years old woman with a diagnosis of systemic lupus erythematosus and scleroderma overlapping syndrome. During treatment with steroids and azathioprine, the appearance of paresthesias and a progressive invalidating proximal weakness was interpreted as a steroidal myopathy. Steroidal treatment was progressively discontinued, but lupic activity and esophageal involvement exacerbated. Therefore, the use of immune modulating doses of intravenous gamma globulin (2 g/kg/total dose) was decided. The patient received this dose in two consecutive days and, 48 hours later, a notable improvement in esophageal function and general condition was verified. After six months of follow up, the disease remains inactive.
Databáze: MEDLINE