[Novel approaches to the study of autoregulation of alternative complement pathway].

Autor: Galebskaia LV; Saint-Petersburg State Pavlov Medical University.
Jazyk: ruština
Zdroj: Voprosy meditsinskoi khimii [Vopr Med Khim] 1998 Sep-Oct; Vol. 44 (5), pp. 501-5.
Abstrakt: Experimental and literary data on the peculiarities of complement alternative pathway (APC) self-regulation and regulation are reviewed. There is a discussion of the methods of APC evaluation, including a new one, called complement hemolytical capacity. It is shown that the duration of complement-dependent hemolysis lag-period is limited by factor D concentration. The phenomenon of acceleration of APC-dependent hemolysis by membranes of lysed cells is described. The latter is an evidence of APC functioning in the mode of double amplification.
Databáze: MEDLINE