| Autor: |
Brouwer DA; Central Laboratory for Clinical Chemistry, University Hospital Groningen, The Netherlands. d.a.j.brouwer@lab.azg.nl, Hettema Y, van Doormaal JJ, Muskiet FA |
| Jazyk: |
angličtina |
| Zdroj: |
Prostaglandins, leukotrienes, and essential fatty acids [Prostaglandins Leukot Essent Fatty Acids] 1998 Nov; Vol. 59 (5), pp. 329-34. |
| DOI: |
10.1016/s0952-3278(98)90082-5 |
| Abstrakt: |
Augmentation of long chain polyunsaturated omega3 fatty acid (LCPUFA omega3) status can be reached by consumption of fish oil or by improvement of the conversion of alpha-linolenic acid (ALA) to LCPUFA omega3. Since gamma-linolenic acid (GLA) might activate the rate-limiting delta-6 desaturation, we investigated whether GLA augments LCPUFA omega3 status. Eight adults received 1.4 g GLA for 4 weeks and subsequently 2.2 g ALA+1.4 g GLA daily during another 4 weeks. Another seven adults received a daily oral dose of 2.2 g ALA for 4 weeks, and subsequently 2.2 g ALA+1.4 g GLA during another 4 weeks. ALA, or ALA+GLA, did not significantly augment EPA and DHA contents. We conclude that the LCPUFA omega3 status can not be improved by supplementation of low dose GLA, neither by co-supplementation of ALA. Poor conversion of ALA to LCPUFA omega3 may be caused by preferential beta-oxidation of ALA, negative feedback of arachidonic acid from the omnivorous diet, or by the low dietary ALA/LA ratio. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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