| Autor: |
He YW; Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA., Deftos ML, Ojala EW, Bevan MJ |
| Jazyk: |
angličtina |
| Zdroj: |
Immunity [Immunity] 1998 Dec; Vol. 9 (6), pp. 797-806. |
| DOI: |
10.1016/s1074-7613(00)80645-7 |
| Abstrakt: |
We have identified RORgamma t, a novel, thymus-specific isoform of the orphan nuclear receptor RORgamma that is expressed predominantly in CD4+ CD8+ double-positive thymocytes. Ectopic expression of RORgamma t protects T cell hybridomas from activation-induced cell death by inhibiting the upregulation of Fas ligand. Following hybridoma stimulation, RORgamma t also inhibits IL-2 production but does not affect the induction of Nur-77 and Egr-3 nor the upregulation of CD69. Both the ligand-binding and DNA-binding domains of RORgamma t are required for this effect. We propose that the role of RORgamma t expression in immature thymocytes is to inhibit Fas ligand expression and cytokine secretion following engagement of their TCR during positive or negative selection. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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