| Autor: |
Matory YL; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. 02115, USA. YMatory@bics.bwh.harvard.edu, Dorfman DM, Chen M, Wu L, Spanjaard RA, Goedegebuure PS, Eberlein TJ |
| Jazyk: |
angličtina |
| Zdroj: |
Pathobiology : journal of immunopathology, molecular and cellular biology [Pathobiology] 1999; Vol. 67 (1), pp. 3-11. |
| DOI: |
10.1159/000028044 |
| Abstrakt: |
We have previously shown that immunologically different mouse mammary cancer cell lines induce antitumor responses after IL2 or IL4 gene transfection. We now report the ability of cytokine-transfected tumors to induce eradication of established wild-type tumor. Animals with 6-day-old tumor treated with IL2-transfected cells also had significantly smaller tumors 2.8 and 1.7 cm2 (EMT6 and 410.4). Findings were similar for IL4-transfected cells. Tumor infiltrating lymphocytes or cells from draining lymph nodes demonstrated tumor-specific in vitro cytotoxicity. Immunohistochemical studies revealed T cell infiltrates in transfected tumors. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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