| Autor: |
Weinder-Wells MA; R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA., Altom J, Fernandez J, Fraga-Spano SA, Hilliard J, Ohemeng K, Barrett JF |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1998 Jan 06; Vol. 8 (1), pp. 97-100. |
| DOI: |
10.1016/s0960-894x(97)10197-4 |
| Abstrakt: |
Ellagic acid was found to inhibit E. coli DNA gyrase supercoiling with approximately the same potency as nalidixic acid. Tricyclic analogs of ellagic acid, which vary in the number and position of the hydroxy groups as well as their replacement with halogens, have been synthesized. The biological activity of these analogs is discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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