Short-term exercise enhances insulin-stimulated GLUT-4 translocation and glucose transport in adipose cells.

Autor: Ferrara CM; Experimental Diabetes, Metabolism, and Nutrition Section, Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA., Reynolds TH, Zarnowski MJ, Brozinick JT Jr, Cushman SW
Jazyk: angličtina
Zdroj: Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 1998 Dec; Vol. 85 (6), pp. 2106-11.
DOI: 10.1152/jappl.1998.85.6.2106
Abstrakt: This investigation examined the effects of short-term exercise training on insulin-stimulated GLUT-4 glucose transporter translocation and glucose transport activity in rat adipose cells. Male Wistar rats were randomly assigned to a sedentary (Sed) or swim training group (Sw, 4 days; final 3 days: 2 x 3 h/day). Adipose cell size decreased significantly but minimally (approximately 20%), whereas total GLUT-4 increased by 30% in Sw vs. Sed rats. Basal 3-O-methyl-D-[14C]glucose transport was reduced by 62%, whereas maximally insulin-stimulated (MIS) glucose transport was increased by 36% in Sw vs. Sed rats. MIS cell surface GLUT-4 photolabeling was 44% higher in the Sw vs. Sed animals, similar to the increases observed in MIS glucose transport activity and total GLUT-4. These results suggest that increases in total GLUT-4 and GLUT-4 translocation to the cell surface contribute to the increase in MIS glucose transport with short-term exercise training. In addition, the results suggest that the exercise training-induced adaptations in glucose transport occur more rapidly than previously thought and with minimal changes in adipose cell size.
Databáze: MEDLINE