| Autor: |
Galloway DC; Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, U.K., McLellan LI |
| Jazyk: |
angličtina |
| Zdroj: |
The Biochemical journal [Biochem J] 1998 Dec 15; Vol. 336 ( Pt 3), pp. 535-9. |
| DOI: |
10.1042/bj3360535 |
| Abstrakt: |
Mutation analysis of putative regulatory elements located in the 5'-flanking region of the gene encoding the regulatory subunit of gamma-glutamylcysteine synthetase (GLCLR) revealed that neither an antioxidant-responsive element (ARE) nor an activator protein-1 (AP-1) site regulates inducible expression by t-butylhydroquinone (tBHQ). The AP-1 site was found to modulate basal expression of GLCLR. A 42 bp region between nucleotides -303 and -344, not containing an ARE, was found to regulate inducible expression of GLCLR by tBHQ. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
