| Autor: |
Chole RA; Department of Otolaryngology, Washington University, St. Louis, MO 63110-1007, USA., Tinling SP, Leverentz E, McGinn MD |
| Jazyk: |
angličtina |
| Zdroj: |
Acta oto-laryngologica [Acta Otolaryngol] 1998 Sep; Vol. 118 (5), pp. 705-11. |
| DOI: |
10.1080/00016489850183223 |
| Abstrakt: |
In this study, the auditory bulla of the gerbil was pressurized, leading to active modeling of the bone of the bulla wall with a significant increase in osteoclast surface and mineral apposition rate. Systemic infusion of L-N(G)-nitro-arginine-methyl ester (L-NAME), an inhibitor of nitric oxide synthase (NOS), inhibited this modeling process. The percentage osteoclast surface (Oc.S/BS) on the inner surface bulla wall was significantly reduced in the L-NAME-treated animals when compared with pressurized saline-treated bullae. Fluorescent bone surface (BSf) mineral apposition rates (MAR) and bone formation rate (BFR) were not significantly different in the pressurized bullae when the L-NAME group was compared with the control (vehicle only) group. However, L-NAME significantly suppressed BSf in the unpressurized bullae. Therefore, it is likely that nitric oxide is a mediator of osteoclastic resorption due to adaptive bone modeling through one or more of the isoforms of NOS. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
