Human GBF1 is a ubiquitously expressed gene of the sec7 domain family mapping to 10q24.

Autor: Mansour SJ; Department of Cell Biology, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada., Herbrick JA, Scherer SW, Melançon P
Jazyk: angličtina
Zdroj: Genomics [Genomics] 1998 Dec 01; Vol. 54 (2), pp. 323-7.
DOI: 10.1006/geno.1998.5563
Abstrakt: We present the cDNA sequence of human GBF1 along with data on expression pattern and genomic attributes. The deduced polypeptide encodes a putative guanine nucleotide exchange factor of 206.5 kDa, containing a centrally positioned Sec7 domain and a proline-rich region at the extreme C terminus. Its mRNA transcripts are found in 17 tissues and cell lines, likely suggesting a housekeeping role for GBF1p. The gene maps to 10q24, 2.33 cR from D10S540. It is fully contained within YAC 822C1 and covers at most 450 kb. Its Sec7 domain-encoding region harbors four introns.
(Copyright 1998 Academic Press.)
Databáze: MEDLINE
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