| Autor: |
Hershberger PM; Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040-8006, USA., Switzer AG, Yelm KE, Coleman MC, Devries CA, Rourke FJ, Davis BW, Kraft WG, Twinem TL, Koenigs PM, Paule SM, Siehnel RJ, Zoutendam PH, Imbus R, Demuth TP Jr |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of antibiotics [J Antibiot (Tokyo)] 1998 Sep; Vol. 51 (9), pp. 857-71. |
| DOI: |
10.7164/antibiotics.51.857 |
| Abstrakt: |
This reports the synthesis and in vitro antimicrobial properties of a series of 2-thioether-linked quinolonyl-carbapenems. Although the title compounds exhibited broad spectrum activity, the MICs were generally higher than those observed for selected benchmark carbapenems, quinolonyl-penems, and quinolones. Enzyme assays suggested that the title compounds are potent inhibitors of penicillin binding proteins and inefficient inhibitors of bacterial DNA-gyrase. Uptake studies indicated that the new compounds are not substrates for the norA encoded quinolone efflux pump. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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