Aspergillus and lung transplant recipients: a mycologic and molecular epidemiologic study.
| Autor: | Brenier-Pinchart MP; Parasitologie-Mycologie Médicale et Moléculaire, Laboratoire Relation Hôte-Agents Pathogènes, Faculté de Médecine, Université Joseph Fourier, Grenoble, France., Lebeau B, Devouassoux G, Mondon P, Pison C, Ambroise-Thomas P, Grillot R |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation [J Heart Lung Transplant] 1998 Oct; Vol. 17 (10), pp. 972-9. |
| Abstrakt: | Background: After lung transplantation, filamentous fungi and more particularly Aspergillus fumigatus are commonly isolated, although the origin of contamination is unclear. Methods: To investigate the fungal flora in bronchoscopic fluids, we retrospectively reviewed 20 cases of lung transplant recipients. Using sequence-specific DNA primers analysis, we typed the clinical strains of A. fumigatus isolated from 6 lung transplant recipients. For 4 of them, the strains of this species were isolated from their environment. Results: At least once 90% of patients had filamentous fungi, and A. fumigatus was the most frequently isolated. Bronchial colonization was detected in 14 patients, invasive bronchial mycosis was diagnosed in 4 others, and no case of invasive pulmonary fungal infection was detected. Genome typing of the 47 clinical strains revealed that a given patient could be affected by several different strains. A very extensive polymorphism existed among the 38 environmental strains. Origin of contamination at home was possible in 1 case and in the hospital in 3 cases. Conclusions: Bronchial colonization is frequent after lung transplantation. Although the clinical strains show a polymorphism, it is less widespread than the polymorphism of environmental strains. The origin of acquisition may be in the patient's community. |
| Databáze: | MEDLINE |
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