| Autor: |
Tamburrini E; Clinic of Infectious Diseases, Catholic University, Rome, Italy., Mencarini P, Visconti E, Zolfo M, Marinaci S, Zinzi D, Margutti P, Ortona E, Siracusano A |
| Jazyk: |
angličtina |
| Zdroj: |
FEMS immunology and medical microbiology [FEMS Immunol Med Microbiol] 1998 Sep; Vol. 22 (1-2), pp. 37-49. |
| DOI: |
10.1111/j.1574-695X.1998.tb01185.x |
| Abstrakt: |
Our aim was to evaluate if genetic diversity of Pneumocystis carinii could influence the detection by molecular techniques in bronchoalveolar lavage (BAL) fluids and in non-invasive specimens (induced sputum, oropharyngeal washing and serum/blood). P. carinii is morphologically similar in different hosts although several strains have been identified by biomolecular techniques. Variations of mt-LSU and ITSs sequences could determine a lack of hybridization of some clinical samples and could have diagnostic consequences with loss in sensitivity and specificity of available molecular tests, but at the moment no data support a significant impact of genetic diversity in these sequences on molecular detection of P. carinii for clinical purposes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text