Anticonvulsant activity of enzyme inhibitors in rats.
Autor: | Ramabadran K, Bansinath M, Guruswami MN |
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Jazyk: | angličtina |
Zdroj: | Journal of pharmaceutical sciences [J Pharm Sci] 1976 Aug; Vol. 65 (8), pp. 1245-6. |
DOI: | 10.1002/jps.2600650829 |
Abstrakt: | Three liver microsomal enzyme inhibitors, proadifen, 2,4-dichloro-6-phenylphenoxyethyldiethylamine, and 2,4-dichloro-6-phenylphenoxyethylamine, and a hepatotoxic agent, carbon tetrachloride, were tested for anticonvulsant activity in adult male albino rats using the maximal electroshock seizure technique. All four substances exhibited significant anticonvulsant activity 1 hr after intraperitoneal administration. This protection was absent when tested 24 hr later. |
Databáze: | MEDLINE |
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