Anticonvulsant activity of enzyme inhibitors in rats.

Autor: Ramabadran K, Bansinath M, Guruswami MN
Jazyk: angličtina
Zdroj: Journal of pharmaceutical sciences [J Pharm Sci] 1976 Aug; Vol. 65 (8), pp. 1245-6.
DOI: 10.1002/jps.2600650829
Abstrakt: Three liver microsomal enzyme inhibitors, proadifen, 2,4-dichloro-6-phenylphenoxyethyldiethylamine, and 2,4-dichloro-6-phenylphenoxyethylamine, and a hepatotoxic agent, carbon tetrachloride, were tested for anticonvulsant activity in adult male albino rats using the maximal electroshock seizure technique. All four substances exhibited significant anticonvulsant activity 1 hr after intraperitoneal administration. This protection was absent when tested 24 hr later.
Databáze: MEDLINE