| Autor: |
Selassie CD; Department of Chemistry, Pomona College, Claremont, California 91711, and Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, USA., Gan WX, Kallander LS, Klein TE |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 1998 Oct 22; Vol. 41 (22), pp. 4261-72. |
| DOI: |
10.1021/jm970776j |
| Abstrakt: |
Quantitative structure-activity relationships (QSAR) have been formulated for a set of 15 2,4-diamino-5-(2-X-benzyl)pyrimidines versus dihydrofolate reductase from Lactobacillus casei and chicken liver. QSARs were also developed for comprehensive data sets containing mono-, di-, and trisubstituted benzyl derivatives. Particular emphasis was placed on the role played by ortho substituents in the overall binding process and subsequent inhibition of the catalytic process in both the prokaryotic and eucaryotic DHFRs. Comparisons between the two QSARs reveal subtle differences at specific positions which can be optimized to design more selective antibacterial agents. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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