Functional determinants by which snake and cone snail toxins block the alpha 7 neuronal nicotinic acetylcholine receptors.

Autor: Servent D; Département d'Ingénierie et d'Etudes des Proteines, CEA-Saclay, Gif-sur-Yvette, France., Thanh HL, Antil S, Bertrand D, Corringer PJ, Changeux JP, Ménez A
Jazyk: angličtina
Zdroj: Journal of physiology, Paris [J Physiol Paris] 1998 Apr; Vol. 92 (2), pp. 107-11.
DOI: 10.1016/s0928-4257(98)80146-0
Abstrakt: Snakes and cone snails produce toxins which block muscular and/or neuronal nicotinic acetylcholine receptors (AChRs). This paper mostly focuses on the determinants by which a snake long chain curaremimetic toxin and the cone snail toxin ImI bind specifically to the alpha 7 neuronal receptor. In both cases, the site involves a small turn-like structure constrained by two half-cystines.
Databáze: MEDLINE