| Autor: |
Vaughan DP, Beckett AH, Robbie DS |
| Jazyk: |
angličtina |
| Zdroj: |
British journal of clinical pharmacology [Br J Clin Pharmacol] 1976 Apr; Vol. 3 (2), pp. 279-83. |
| DOI: |
10.1111/j.1365-2125.1976.tb00604.x |
| Abstrakt: |
The cumulative urinary excretion over 24 h of pentazocine, under conditions of acidic urinary pH, has been measured in smokers and non-smokers using both male and female subjects (seventy subjects in total). A restricted urban population was studied. An overall three-fold inter-subject variation in elimination was observed. The cumulative urinary excretion of pentazocine was normally distributed in both smokers and non-smokers. Smokers metabolize 40% more pentazocine than non-smokers. It is concluded that induction is principally responsible for the observed subject variability. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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