| Autor: |
Faraci WS; Central Research Division, Pfizer Central Research, Groton, CT 06340, USA., Zorn SH, Sanner MA, Fliri A |
| Jazyk: |
angličtina |
| Zdroj: |
Current opinion in chemical biology [Curr Opin Chem Biol] 1998 Aug; Vol. 2 (4), pp. 535-40. |
| DOI: |
10.1016/s1367-5931(98)80131-2 |
| Abstrakt: |
The identification of a novel dopamine receptor subtype, referred to as the D4 receptor, which binds the atypical antipsychotic drug clozapine with high potency, has led to the initiation of a drug discovery program that aims to find novel inhibitors of this receptor subtype. A selective screening strategy was utilized, in which 4500 compounds chosen on the basis of structural similarities to known biogenic amine receptor antagonists were tested against both the D4 and D2 dopamine receptor subtypes. A potent D4-selective compound was discovered. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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