Rothmund-Thomson syndrome and tolerance of chemoradiotherapy.

Autor: Borg MF; Royal Adelaide Hospital Cancer Centre, Royal Adelaide Hospital, Australia., Olver IN, Hill MP
Jazyk: angličtina
Zdroj: Australasian radiology [Australas Radiol] 1998 Aug; Vol. 42 (3), pp. 216-8.
DOI: 10.1111/j.1440-1673.1998.tb00496.x
Abstrakt: Rothmund-Thomson syndrome (RTS) is a rare disorder with a predisposition for cutaneous and non-cutaneous malignancy. It is speculated that ultraviolet (UV) sensitivity and deficient DNA repair may account for this predisposition and influence the tolerance of chemoradiotherapeutic management. A case is reported of the management of an RTS patient with squamous cell carcinoma of the tongue who demonstrated increased radiosensitivity and tissue intolerance to chemotherapy.
Databáze: MEDLINE