| Autor: |
Bengtsson H; Department of Neuroscience, Uppsala University, Biomedical Center, Sweden. henrik.bengtsson@mun.uu.se, Söderström S, Kylberg A, Charette MF, Ebendal T |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of neuroscience research [J Neurosci Res] 1998 Sep 01; Vol. 53 (5), pp. 559-68. |
| DOI: |
10.1002/(SICI)1097-4547(19980901)53:5<559::AID-JNR6>3.0.CO;2-8 |
| Abstrakt: |
mRNA for bone morphogenetic protein receptor type II (BMPR-II) was mapped to different neurons in peripheral ganglia and spinal cord of the chicken embryo. The expression of this serine/threonine kinase receptor partially overlaps with that of tyrosine kinase receptors Trk and Ret. Biological activities of osteogenic protein-1 (OP-1), a documented ligand for BMPR-II, were tested in explanted embryonic chicken ganglia and dissociated ganglionic neurons. OP-1 had only a limited stimulatory effect on neuronal survival. However, OP-1 combined with either neurotrophin-3 (NT-3, a relative of nerve growth factor) or glial cell line-derived neurotrophic factor (GDNF) potentiated neuronal survival three- to fourfold. We also show that OP-1 strongly potentiates nerve fiber outgrowth from ganglia stimulated with NT-3 or GDNF. Signaling by BMPR-II in neurons may potentiate the tyrosine kinase pathway activated by NT-3 and GDNF. The data suggest that morphogenetic proteins may modulate neurotrophic activities during neuronal development and plasticity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text