A synthetic strategy to a new class of cycloalkane ring-fused pyridine nucleosides as potential anti HIV agents.

Autor: Elgemeie GE; Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt., Attia AM, Hussain BA
Jazyk: angličtina
Zdroj: Nucleosides & nucleotides [Nucleosides Nucleotides] 1998 May; Vol. 17 (5), pp. 855-68.
DOI: 10.1080/07328319808003458
Abstrakt: Condensation of cyanothioacetamide or cyanoacetamide with sodium salts of 2-formyl-1-cycloalkanones afforded the corresponding cycloalkane ring fused pyridine-2(1H)-thiones and -2-pyridones. The latter compounds served as a key intermediates for the synthesis of a new class of cycloalkane ring fused pyridine glycosides.
Databáze: MEDLINE