Ammoniation to reduce the toxicity of endophyte-infected tall fescue seed fed to rats.

Autor: Simeone A; Department of Animal Sciences, University of Kentucky, Lexington 40546, USA., Westendorf ML, Tucker RE, Bush LP, Mitchell GE Jr
Jazyk: angličtina
Zdroj: Drug and chemical toxicology [Drug Chem Toxicol] 1998 Aug; Vol. 21 (3), pp. 373-85.
DOI: 10.3109/01480549809002212
Abstrakt: To assess the efficacy of ammoniation in the detoxification of endophyte-infected tall fescue (Festuca arundinacea Schreb), 40 male Harlan Sprague-Dawley rats were randomly assigned to the following four treatments for 28 d: endophyte-free (E-), endophyte-infected (E+), ammoniated (2% dry matter basis, 7 d) endophyte-free (AE-), and ammoniated endophyte-infected (AE+) tall fescue seed. Total pyrrolizidine alkaloid (N-acetyl and N-formyl loline) and ergovaline contents of endophyte-infected fescue seed were reduced 24 and 54%, respectively, by ammoniation. Endophyte-infected treatment groups had lower (P < 0.01) daily feed intakes (DFI), daily weight gains (DWG), feed efficiencies, and primary serum hemagglutination titers to sheep red blood cell (SRBC) immunization than endophyte-free treatment groups. Performance parameters were higher (P < 0.01) for ammoniated diets in comparison to non-ammoniated diets; however, anti-SRBC titers were not significantly different. When compared to the E+ diet, the AE+ diet increased (P < 0.01) DFI (24%), DWG (41%) and feed efficiency (13%).
Databáze: MEDLINE