| Autor: |
Ledru E; Centre Muraz (Organisation de Coordination et de Coopération pour la Lutte contre les Grandes Endémies) Bobo-Dioulasso, Burkina Faso, Africa. eriledru@pasteur.fr, Diagbouga S, Meda N, Sanou PT, Dahourou H, Ledru S, Dembelé A, Zoubga A, Durand G |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of STD & AIDS [Int J STD AIDS] 1998 Aug; Vol. 9 (8), pp. 463-70. |
| DOI: |
10.1258/0956462981922638 |
| Abstrakt: |
Our objective was to propose a strategy to screen HIV-infected African people for biological immunodeficiency easily. In a cross-sectional study, we analysed the patterns of diseases and of CD4 counts among 266 HIV-infected adults. Peripheral facial paralysis and chronic cutaneo-mucous diseases were the earlier B-stage diseases. Pulmonary tuberculosis was close to B-stage diseases, and chronic diarrhoea was borderline between B and C stages. Cachexia was the most frequent C-stage symptom (47.8%). Ninety per cent of CDC-C stage people had CD4 counts below 350/microliter, whereas only 75% had CD4 counts below 200/microliter. Regression analysis identified the lymphocyte count, clinical stage and platelet count as predictors of CD4 count below 350/microliter. A simple score (lymphocyte count < or = 2500/microliter and clinical stage > or = B) is proposed to determine this CD4 threshold (positive predictive value: 83%) and to determine those patients needing treatment to prevent wasting and opportunistic infections. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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