| Autor: |
Levine RL; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2196, USA., Cargile CB, Blazes MS, van Rees B, Kurman RJ, Ellenson LH |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer research [Cancer Res] 1998 Aug 01; Vol. 58 (15), pp. 3254-8. |
| Abstrakt: |
The two most common types of genetic alterations yet identified in uterine endometrioid carcinoma (UEC) are PTEN mutations and microsatellite instability (MI). Furthermore, MI-positive UECs (defined as tumors with detectable alterations at two or more different microsatellite loci) are significantly more likely to contain PTEN mutations than are MI-negative UECs. To determine whether PTEN inactivation is a relatively early event in endometrial tumorigenesis, we evaluated complex atypical hyperplasia (CAH), the direct precursor to UEC, for the presence of PTEN mutations. Mutations were present in 3 of 11 (27%) CAHs with synchronous UEC and in 4 of 18 (22%) CAHs that were not associated with invasive carcinoma. One case with synchronous CAH and UEC contained a germ-line PTEN mutation. In addition, we evaluated the same series of CAHs for MI. We identified four MI-positive CAHs with synchronous UEC but did not detect the MI phenotype in any CAHs without associated invasive carcinoma. A PTEN-mutant (germ-line mutation) MI-negative CAH was synchronous with a PTEN-mutant MI-positive UEC. These results suggest that mutation of PTEN can be an early event in the pathogenesis of UEC and may precede the development of the MI phenotype in a subset of cases. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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