| Autor: |
Kurada P; Department of Biological Sciences, University of Notre Dame, IN 46556, USA., Tonini TD, Serikaku MA, Piccini JP, O'Tousa JE |
| Jazyk: |
angličtina |
| Zdroj: |
Visual neuroscience [Vis Neurosci] 1998 Jul-Aug; Vol. 15 (4), pp. 693-700. |
| DOI: |
10.1017/s0952523898154093 |
| Abstrakt: |
ninaE(D1), a dominant allele of the major Drosophila rhodopsin gene, expresses a rhodopsin that is predominantly recovered in a 80-kD complex that likely represents rhodopsin dimers. By driving either ninaE(D1) or ninaE+ expression from a heat-shock promoter, we show that the 80-kD rhodopsin complex forms immediately after gene activation. In wild type, but not ninaE(D1), rhodopsin monomeric forms are detected at later times. The generation of monomeric forms of wild-type rhodopsin is suppressed in vitamin A-deprived flies or in flies heterozygous for the dominant rhodopsin mutation. We also show that ninaE(D1) expression does not affect the maturation of another Drosophila visual pigment, Rh3. These results are consistent with the view that the ninaE(D1) rhodopsin antagonizes an early posttranslation process that is specific for maturation of the ninaE-encoded rhodopsin. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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