| Autor: |
Brouwer DA; Central Laboratory for Clinical Chemistry, Groningen University Hospital, The Netherlands. d.a.j.brouwer@lab.azg.nl, Welten HT, Reijngoud DJ, van Doormaal JJ, Muskiet FA |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical chemistry [Clin Chem] 1998 Jul; Vol. 44 (7), pp. 1545-50. |
| Abstrakt: |
We established the cutoff value for plasma folic acid, using plasma homocyst(e)ine as the functional marker. To do this, we investigated the relationship of the plasma folic acid of 103 apparently healthy adults with their fasting plasma homocyst(e)ine and with their plasma homocyst(e)ine 6 h after oral methionine challenge (100 mg/kg). We also studied the relationship of their plasma folic acid with the decline of fasting plasma homocyst(e)ine after 7 days of folic acid supplementation (5 mg/day). The three approaches suggested a cutoff value of 10 nmol/L. The chances of individuals to significantly (P <0.05) lower their plasma homocyst(e)ine after folic acid supplementation proved significantly higher at plasma folic acid concentrations < or = 10 nmol/L, as compared with folic acid concentrations above this value (odds ratio, 5.02; 95% confidence interval, 1.87-13.73). We suggest adopting a 10 nmo/L plasma folic acid cutoff value on functional grounds. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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