Acalculous ischemic gallbladder necrosis in the catastrophic antiphospholipid syndrome.

Autor: Desailloud R; Centre Hospitalier de Valenciennes, France., Papo T, Vaneecloo S, Gamblin C, Vanhille P, Piette JC
Jazyk: angličtina
Zdroj: Arthritis and rheumatism [Arthritis Rheum] 1998 Jul; Vol. 41 (7), pp. 1318-20.
DOI: 10.1002/1529-0131(199807)41:7<1318::AID-ART24>3.0.CO;2-K
Abstrakt: A 29-year-old woman was referred for abdominal pain. Results of tests for lupus anticoagulant and antibodies to phosphatidylserine and to beta2-glycoprotein I were positive, but the patient had no features of systemic lupus erythematosus (SLE). Abdominal ultrasonography showed a thickening of the gallbladder wall without cholelithiasis. A surgical procedure revealed necrotic areas of the gallbladder wall, and a cholecystectomy was performed. Histologic examination of the gallbladder showed multiple thrombi and no vasculitis. Despite full-dose heparin, the patient developed a catastrophic antiphospholipid syndrome (APS) and subsequently died. Among connective tissue disorders, acute acalculous cholecystitis has been reported in patients with polyarteritis nodosa and/or SLE. APS should be considered as a possible cause of acalculous cholecystitis.
Databáze: MEDLINE