| Autor: |
Fogelson BG; Department of Surgery, University of Illinois at Chicago College of Medicine, 60612, USA., Nawas SI, Vigneswaran WT, Ferguson JL, Law WR, Sharma AC |
| Jazyk: |
angličtina |
| Zdroj: |
Diabetes [Diabetes] 1998 Jul; Vol. 47 (7), pp. 1161-3. |
| DOI: |
10.2337/diabetes.47.7.1161 |
| Abstrakt: |
Diabetes is associated with altered vascular responses, and diabetic patients demonstrate increased morbidity and mortality after coronary artery bypass grafting (CABG). We tested whether endothelin (ET)-1 levels in this patient population differed from those in nondiabetic subjects after CABG. Of 14 consecutive patients who underwent CABG by the same surgeon, 7 had type 2 diabetes and 7 were nondiabetic. The two groups did not differ significantly in preoperative ejection fraction, number of vessels bypassed, cross-clamp time, or Parsonnet's score. Coronary sinus blood samples were obtained before cardioplegic arrest and then obtained at 1 and 15 min after each of two reperfusion periods: reperfusion A (native coronary perfusion plus the left internal mammary artery), reperfusion B (saphenous vein graft perfusion). ET-1 was significantly increased at all reperfusion time points in diabetic patients compared with nondiabetic patients. In diabetic patients, reperfusion after CABG can trigger the release of ET-1, which may be a contributing factor in the increased cardiac morbidity seen in this patient population. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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