Adhesion molecules in iris biopsy specimens from patients with uveitis.
| Autor: | La Heij E; Department of Ophthalmology, University Hospital Rotterdam, Dijkzigt, Netherlands., Kuijpers RW, Baarsma SG, Kijlstra A, van der Weiden M, Mooy CM |
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| Jazyk: | angličtina |
| Zdroj: | The British journal of ophthalmology [Br J Ophthalmol] 1998 Apr; Vol. 82 (4), pp. 432-7. |
| DOI: | 10.1136/bjo.82.4.432 |
| Abstrakt: | Background/aims: Earlier studies on intraocular tissue have demonstrated that T lymphocytes play a major role in the pathogenesis of uveitis. Adhesion molecules are immunoregulatory molecules for the interaction between T lymphocytes and vascular endothelium and they play an important role in the recruitment of specific T lymphocytes from the circulation into inflamed tissue. In uveitis an increased expression of some of these adhesion molecules may be expected. Methods: The presence of adhesion molecules was investigated in iris biopsy specimens from 11 patients with uveitis and eight controls (patients with primary open angle glaucoma) immunohistochemically with a panel of monoclonal antibodies: LECAM (CD 62L), ICAM-1 (CD 54), LFA-1 (CD 11a/18), VCAM-1 (CD 106), VLA-4 (CD 49d), and HECA-452, a marker for high endothelial venules. Results: Positive staining for ICAM-1, LFA-1 and VCAM-1 was found in the iris in a significantly higher number of uveitis patients than in controls. The remaining adhesion molecules were also found in a higher number of uveitis patients than in controls, but this difference did not reach statistical significance. Conclusion: An increased expression of adhesion molecules was found in the iris of patients with uveitis, indicating an immunoregulatory function for adhesion molecules in the pathogenesis of uveitis. |
| Databáze: | MEDLINE |
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