| Autor: |
Katz IA; Department of Biochemistry, Royal North Shore Hospital, St Leonards, NSW, Australia. kitkatz@bigpond.com.au, Irwig L, Vinen JD, March L, Wyndham LE, Luu T, Nelson GI |
| Jazyk: |
angličtina |
| Zdroj: |
Annals of clinical biochemistry [Ann Clin Biochem] 1998 May; Vol. 35 ( Pt 3), pp. 393-9. |
| DOI: |
10.1177/000456329803500308 |
| Abstrakt: |
We investigated the early diagnostic utility, including incremental value, of the serum cardiac markers creatine kinase (CK), CK-MB (mass and activity measurements), cardiac troponin T, and myoglobin in the diagnosis of acute myocardial infarction (AMI) in patients presenting to a major teaching hospital with chest pain and non-diagnostic electrocardiographs (ECG). The reference diagnosis of acute myocardial infarction was made by a single, independent cardiologist using World Health Organization criteria. CK and CK-MB mass were the only significant predictors of AMI at presentation to the Emergency Department. Logistic regression analysis revealed that CK did not significantly predict (P = 0.23) myocardial infarction once CK-MB mass was in the model. Using test results on follow up, in addition to presentation CK-MB mass, change in CK-MB mass was the only other significant independent predictor of AMI. Likelihood ratios for various levels of the significant markers in the logistic regression are given. In conclusion, CK-MB mass measurement was the only useful serum cardiac marker for the diagnosis of AMI in patients presenting with chest pain with non-diagnostic ECGs. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
