| Autor: |
Sant VP; Bharati Vidyapeeth's Poona College of Pharmacy, Erandwane, Pune, Maharashtra, India., Khopade AJ, Jain NK |
| Jazyk: |
angličtina |
| Zdroj: |
Die Pharmazie [Pharmazie] 1998 May; Vol. 53 (5), pp. 334-6. |
| Abstrakt: |
The influence of pulsed current duty cycle, addition of electrically neutral species and pH on iontophoretic transdermal delivery of an organic ion-pair salbutamol:methyl orange through excised rabbit abdominal skin is described. It was compared with salbutamol sulphate and salbutamol:sulphate ion-pair. It was found that there exists an optimum duty cycle range (1:3-1:4) at which iontophoretic flux of the ion-pair was at a maximum because of partition-electric current synchronization. Addition of mannitol decreases the flux of the ion-pair showing the important role of electroosmosis in ion-pair transport. The extremes of pH decrease the flux rates. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
