| Autor: |
Cui B; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612, USA., Chai H, Constant HL, Santisuk T, Reutrakul V, Beecher CW, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD |
| Jazyk: |
angličtina |
| Zdroj: |
Phytochemistry [Phytochemistry] 1998 Apr; Vol. 47 (7), pp. 1283-7. |
| DOI: |
10.1016/s0031-9422(97)00711-5 |
| Abstrakt: |
Activity-directed fractionation of a stem extract of Azadirachta excelsa using KB (human oral epidermoid carcinoma) cells led to the isolation of four meliacin-type limonoids. Two of these constituents were novel, namely, 2,3-dihydronimbolide and 3-deoxymethylnimbidate, and these were purified along with the known compounds, nimbolide and 28-deoxonimbolide. The structures of the new compounds were determined by spectroscopic methods. Nimbolide and 28-deoxonimbolide were broadly cytotoxic when evaluated against a panel of human cancer cell lines, while the two novel compounds were inactive in this regard. The defection of nimbolide and 28-deoxonimbolide as cytotoxic constituents was facilitated by an electrospray LC/MS dereplication procedure. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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