| Autor: |
D'Olhaberriague L; Department of Neurology, Henry Ford Hospital & Health Sciences Center, Detroit, MI 48202, USA., Welch KM, Nagesh V, Gymnopoulos C, Mansbach HH, Hugg JW, Boska MD, Knight RA, Schultz LR, Levine SR, Chopp M |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the neurological sciences [J Neurol Sci] 1998 Apr 01; Vol. 156 (2), pp. 158-66. |
| DOI: |
10.1016/s0022-510x(97)00211-6 |
| Abstrakt: |
We evaluated the ability of an MR signature model (SM) of cerebral ischemic injury to stage the evolution of cellular damage in human stroke. In 19 patients with ischemic stroke of presumed embolic or non-embolic cause we carried out diffusion-weighted and T2-weighted MR imaging within 48 h of onset, and obtained apparent diffusion coefficient of water (ADCw), and T2 weighted images. We used the signatures obtained from these ADCw/T2 maps to formulate two patterns of damage signifying accelerated or non-accelerated progression of cellular death after stroke onset. Those patients with the accelerated pattern corresponded to those with the neuroradiological (NRC) and clinical diagnosis (TOAST.1 and TOAST.2) of presumed embolic stroke, with clinical diagnosis performed blinded both to NRC and to SM. Agreement between the SM and NRC was substantial (kappa=0.62), moderate (0.60
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| Databáze: |
MEDLINE |
| Externí odkaz: |
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