[Evaluation of combination RU 486-laminaria tents-misoprostol-peridural anesthesia in second and third trimester induced abortions].

Autor:	Hoffer MC; Unité de Médecine Foetale, Fédération des Services de Gynécologie-Obstétrique, Hôpital Arnaud de Villeneuve, Montpellier., Charlier C, Giacalone PL, Zimbris L, Astruc M, Boulot P
Jazyk:	francouzština
Zdroj:	Journal de gynecologie, obstetrique et biologie de la reproduction [J Gynecol Obstet Biol Reprod (Paris)] 1998 Jan; Vol. 27 (1), pp. 83-6.
Abstrakt:	Objective: To evaluate a new protocol for mid and third trimester medical termination of pregnancy using RU 486-misoprostol-epidural analgesia. Design and Setting: Monocentric, prospective and descriptive study in a teaching hospital. Materials and Methods: Eighty-three women undergoing legal induced abortion during the second and third trimester. Administration of 600 mg mifepristone 36 hours prior to laminaria tents. 48 hours after RU 486, misoprostol was orally given on a 3 hours basis. Epidural analgesia was systematically performed. Main Outcome Measures: Induction-abortion interval, median dose of misoprostol, maternal complications, number of fetal autopsies obtained within 24 hours. Results: The mean induction abortion interval was 3 h for multiparas and 4.45 h for nulliparas. The median dose of misoprostol was 800 micrograms. A uterine rupture on a scarred uterus occurred. The rate of fetal autopsies in cases of malformations within 24 hours reached 96%. Conclusions: This protocol allows a safe, rapid, cheap and painless late termination of pregnancy, when compared to other protocols.
Databáze:	MEDLINE
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