| Autor: |
Fecik RA; Department of Medicinal Chemistry, Kansas University, Lawrence 66045-2506, USA., Frank KE, Gentry EJ, Menon SR, Mitscher LA, Telikepalli H |
| Jazyk: |
angličtina |
| Zdroj: |
Medicinal research reviews [Med Res Rev] 1998 May; Vol. 18 (3), pp. 149-85. |
| DOI: |
10.1002/(sici)1098-1128(199805)18:3<149::aid-med2>3.0.co;2-x |
| Abstrakt: |
The literature of combinatorial chemistry is reviewed with particular attention paid to considerations of absorption, distribution, metabolism and excretion in the design and evaluation of libraries containing drug-like molecules. Published libraries are evaluated in particular for the likelihood that the products would possess oral bioavailability. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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