| Autor: |
Schwartz JE; Division of Neonatology, Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA., Kovach A, Meyer J, McConnell C, Iwamoto HS |
| Jazyk: |
angličtina |
| Zdroj: |
Biology of the neonate [Biol Neonate] 1998; Vol. 73 (5), pp. 313-9. |
| DOI: |
10.1159/000013990 |
| Abstrakt: |
This study was conducted to determine whether brief, intermittent exposure to hypoxia with little change in nutrient intake would affect fetal growth. Pregnant rats were exposed to 1 or 2 h of hypoxia (FiO2 = 0.09-0.095) from days 15 to 19 of gestation. Exposure to 1 h of hypoxia decreased fetal body weight and length, liver weight and increased the brain/liver weight ratio (p < 0.05) as compared to controls. Two hours of hypoxia decreased fetal body weight and length, and heart, lung, kidney, gut, brain and liver weights (p < 0.01), but did not affect the brain/liver weight ratio. Two hours of hypoxia decreased maternal food intake and weight gain (p < 0.05), but fetal growth was not significantly altered in pair-fed controls. These data demonstrate that brief, intermittent periods of intrauterine hypoxia have significant effects on fetal growth. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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