E-cadherin and calretinin: a useful combination of immunochemical markers for differentiation between mesothelioma and metastatic adenocarcinoma.
| Autor: | Leers MP; Department of Pathology, De Wever Hospital, Heerlen, The Netherlands., Aarts MM, Theunissen PH |
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| Jazyk: | angličtina |
| Zdroj: | Histopathology [Histopathology] 1998 Mar; Vol. 32 (3), pp. 209-16. |
| DOI: | 10.1046/j.1365-2559.1998.00349.x |
| Abstrakt: | Aims: To assess the diagnostic accuracy of combinations of antibodies in the differential diagnosis of metastatic carcinomas and mesotheliomas in pleural lesions. Methods and Results: The specificity and sensitivity of the commercially available antibodies Ber-EP4, MOC-31, CEA, B72.3, CD15, E-cadherin and calretinin were evaluated using an indirect immunoperoxidase staining technique. This technique was applied to formalin-fixed, paraffin-embedded tissue blocks of pleural lesions. Twenty-one patients with metastatic carcinoma (MC) and 20 patients with malignant mesothelioma (MM) were included. The combination E-cadherin/calretinin had the highest specificity (MC 100% and MM 91%) and sensitivity (MM 100% and MC 91%) considering both categories of tumours. Conclusions: The combination of E-cadherin/calretinin appears to be a suitable panel for distinguishing metastatic carcinomas and mesotheliomas in pleural lesions. The additional value of other markers is limited. |
| Databáze: | MEDLINE |
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