| Autor: |
Vij AG; Defence Institute of Physiology and Allied Sciences, Timarpur, Delhi, India., Satija NK, Flora SJ |
| Jazyk: |
angličtina |
| Zdroj: |
Biomedical and environmental sciences : BES [Biomed Environ Sci] 1998 Mar; Vol. 11 (1), pp. 7-14. |
| Abstrakt: |
Effect of vitamin C supplementation in restoring lead induced alterations in hematopoietic system and drug metabolizing enzymes were investigated in male rats. Intraperitoneal administration of 20 mg/kg lead produced a significant inhibition of heme synthesis in blood and liver and drug metabolism in liver. Toxic insult by lead also resulted into a marked decline in tissue thiols and vitamin C levels. Oral supplementation of vitamin C (100 mg/kg for 3 days) completely restored blood delta aminolevulinic acid dehydratase, uroporphyrinogen I synthetase and a few drug metabolizing enzymes. Level of vitamin C and sulfhydryl contents too recovered to a great extent. A marked reduction in blood and liver lead concentration occurred on vitamin C supplementation although renal lead contents were marginally reduced in lead exposed animals. The results, thus, indicate a significant protective action of vitamin C against toxic effects of lead on heme synthesis and drug metabolism. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
