| Autor: |
Velický J; Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague., Titlbach M, Lojda Z, Dusková J, Vobecký M, Strbák V, Raska I |
| Jazyk: |
angličtina |
| Zdroj: |
Acta histochemica [Acta Histochem] 1998 Feb; Vol. 100 (1), pp. 11-23. |
| DOI: |
10.1016/S0065-1281(98)80003-2 |
| Abstrakt: |
Male rats fed by a standard diet with determined of bromine and iodine content were exposed to a 133-day oral administration of KBr (100, 200, 400 mg Br-/l drinking water). Their thyroid glands showed increased growth of the epithelial cells reflected by a microfollicular rearrangement of the parenchyma due to proliferation of very small follicles with a low or zero content of colloid. Morphometric analysis of thyroids of Br(-)-exposed animals revealed a significant decrease in the volume of intrafollicular colloid and marked increase in the number of the smallest follicles (areas up to 100 and 100-300 micron 2). In addition, the nuclei of thyrocytes showed an increased number of mitoses. The vascularization was increased as well. In the blood plasma of the Br(-)-exposed animals the T4 concentration was significantly decreased in dependence on the bromine concentrations. Thyroglobulin immunoreactivity in the colloid of Br(-)-exposed animals decreased after administration of 400 mg Br-/l drinking water. Increasing concentrations of Br- in the drinking water caused an increased bromine concentration in the thyroid, a decreased iodine content and a decreased I/Br molar ratio. The changes in the rat thyroid caused by long-term administration of 100 mg Br-/l were similar to hyperplastic parenchymal goitre and were comparable to those induced in previous experiments by the same bromine concentration administered over a 16- and 66-day period respectively. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full Text from ScienceDirect